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Only one previous randomised clinical trial has evaluated the use of methylene blue in patients with post cardiac surgery vasoplegia (Levin et al. 2004). A total of 56 patients with post cardiopulmonary bypass vasoplegia were included. Of these, 28 received an infusion of 1.5 mg/kg of methylene blue over 1 hour and 28 received placebo.
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Before performing the anastomosis, 2.5 mg of ICG dye can be injected intravenously, which is based on the doses used in most of the clinical trials. 197-200, 202, 203 However, most studies in colorectal surgery used ICG injection doses varying from 0.2 to 0.5 mg/kg. 206, 213, 221, 223, 224 Nevertheless, it was shown that the colorectal.
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Intravenous methylene blue was successfully first used in humans in 2013 demonstrating its feasibility for open pelvic surgery . Two small studies explored the use of methylene blue fluorescence in laparoscopic surgery [13, 14]. Methylene blue proved to be useful in eight patients using an in-house manufactured laparoscopic system, highlighting.
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Methylene blue is available for use as an intraoperative adjunct to aid localization of enlarged parathyroid glands during surgery for hyperparathyroidism. This technique was pioneered by Dudley in 1971 1 and has since been implemented by many other surgeons 2-6. The benefits of using methylene blue in parathyroid surgery have not been defined.
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Methylene Blue acts by inhibiting guanylate cyclase, thus decreasing C-GMP and vascular smooth muscle relaxation. 9. Preoperative use in cardiac surgery. Methylene blue (1%) has been used IV over 30 min in ICU 1hour before surgery and found decreased incidence and severity of Vasoplegic syndrome in high risk patients. 4. Intraoperative
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Methylene blue is a fluorescent dye discovered in 1876 and has since been used in different scientific fields. Only recently has methylene blue been used for intraoperative fluorescent imaging. Here, the authors review the emerging role of methylene blue, not only as a dye used in clinical practice, but also as a fluorophore in a surgical setting.
The methylene blue adsorption process (100 ppm) by each sample Download Scientific Diagram
There is evidence that new therapeutic strategies can lead to a reduction in norepinephrine doses and mortality in CVS. Specifically, the use of non-adrenergic vasopressors such as methylene blue (MB) can be beneficial. We retrospectively analyzed the electronic records of 8716 adult cardiac surgery patients from November 2008 to December 2016.
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Vasoplegic syndrome, defined by hypotension despite normal or increased cardiac output, is associated with high mortality rate after cardiopulmonary bypass. Methylene blue (MB) is reported to ameliorate vasoplegic syndrome through the nitric oxide pathway. We hypothesized that early administration of MB would improve outcomes in patients with vasoplegic syndrome after cardiopulmonary bypass.
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Blue-tinged urine continued for up to four postoperative days and was evidenced in 37.9% of the patients of the group who used methylene blue (p-value 0.05) and in none of the control group. This was the only characteristic with significantly difference between the two groups.
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Methylene blue injection is used to treat a condition called methemoglobinemia. This condition occurs when the blood cannot deliver oxygen where it is needed in the body. This medicine is to be given only by or under the supervision of a doctor. This product is available in the following dosage forms:
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Methylene blue is a kind of biological dye with multiple medical applications and is often used for localization of sentinel lymph nodes. 1 Studies have shown that methylene blue is an effective local analgesic after anorectal surgery. 2 Recently, methylene blue has been found to be safe and effective in relieving pain in the donor site for a.
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Abstract. Methylene blue has been used to help facilitate parathyroid surgery for over 30 years. Its use has been widely considered both safe and cost effective. Twenty-six cases of a toxic metabolic encephalopathy, however, have been reported with its use. As a result, some surgeons have stopped using this technique altogether.
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If methylene blue may be used during surgery, the suggestion is for discontinuation of the serotonergic psychiatric drug 2 weeks prior to surgery for clearance of the active ingredient and its active metabolites. Fluoxetine or Prozac has an even longer half-life and should be discontinued 5 weeks prior to methylene blue administration.
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Methylene BlueGuided Debridement as an Intraoperative Adjunct for the Surgical Treatment of
The dye methylene blue (MB) has been used as to prevent vasodilatation in other clinical situations like sepsis, cardiopulmonary bypass and liver transplantation. We describe its use in a patient with poor hemodynamic status, who was submitted to aortic aneurism repair with infrarenal cross clamp.
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Hydrotubation using methylene blue confirmed bilateral tubal obstruction at the distal end of ampulla. With the consent from her husband, salpingostomy on both ampulla were performed. Methylene blue was used after salpingostomy to confirm the patency of the bilateral tubes. After the surgery due to personal reasons she took contraception for.